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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551095
Species: Mus musculus
RGD Object: Gene
Symbol: Rela
Name: v-rel reticuloendotheliosis viral oncogene homolog A (avian)
Acc ID: CHEBI:35455
Term: 1-naphthyl isothiocyanate
Definition: An isothiocyanate that has formula C11H7NS.
Chemical ID: MESH:D015058
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Relaaffects localizationEXP 6480464CTD1-Naphthylisothiocyanate affects the localization of RELA proteinPMID:27853831
Relaincreases expressionEXP 6480464CTD1-Naphthylisothiocyanate results in increased expression of RELA mRNA; 1-Naphthylisothiocyanate results in increased expression of RELA proteinPMID:29660435
Relaincreases phosphorylationEXP 6480464CTD1-Naphthylisothiocyanate results in increased phosphorylation of RELA proteinPMID:33749747
Relamultiple interactionsEXP 6480464CTD[Hypoxanthine co-treated with potassium oxonate] inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of RELA protein]; NR1H4 inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]; NR1H4 promotes the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]]; obeticholic acid inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]; pregna-4,17-diene-3,16-dione inhibits the reaction [yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]]; pregna-4,17-diene-3,16-dione promotes the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]; Uric Acid inhibits the reaction [1-Naphthylisothiocyanate results in increased phosphorylation of RELA protein]; yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA mRNA]; yangonin inhibits the reaction [1-Naphthylisothiocyanate results in increased expression of RELA protein]PMID:29660435 PMID:33749747
Relaincreases localizationISORela (Rattus norvegicus)6480464CTD1-Naphthylisothiocyanate results in increased localization of RELA proteinPMID:18590720
Relamultiple interactionsISORela (Rattus norvegicus)6480464CTDDexamethasone promotes the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]; Emodin inhibits the reaction [1-Naphthylisothiocyanate results in increased localization of RELA protein]PMID:18590720
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