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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1551009
Species: Mus musculus
RGD Object: Gene
Symbol: Map1lc3b
Name: microtubule-associated protein 1 light chain 3 beta
Acc ID: CHEBI:4629
Term: diosgenin
Definition: A sapogenin that is spirostan which is substituted by a hydroxy group at the 3beta position, contains a double bond at the 5-6 position, and has R- configuration at position 25. A natural product found in Dioscorea (wild yam) species, it is used as the starting point for the commercial synthesis of a number of steroids, including cortisone, pregnenolone and progesterone.
Chemical ID: MESH:D004144
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Map1lc3bdecreases lipidationISOMAP1LC3B (Homo sapiens)6480464CTDDiosgenin results in decreased lipidation of MAP1LC3B proteinPMID:35149085
Map1lc3bdecreases lipidationISOMap1lc3b (Rattus norvegicus)6480464CTDDiosgenin results in decreased lipidation of MAP1LC3B proteinPMID:35149085
Map1lc3bmultiple interactionsISOMAP1LC3B (Homo sapiens)6480464CTD3-methyladenine inhibits the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; [alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein; alpha-Chlorohydrin inhibits the reaction [Diosgenin results in decreased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; Diosgenin promotes the reaction [alpha-Chlorohydrin results in increased lipidation of MAP1LC3B protein]PMID:35149085
Map1lc3bmultiple interactionsISOMap1lc3b (Rattus norvegicus)6480464CTD[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein; alpha-Chlorohydrin inhibits the reaction [Diosgenin results in decreased lipidation of MAP1LC3B protein]PMID:35149085
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