Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550809
Species: Mus musculus
RGD Object: Gene
Symbol: Tsc22d3
Name: TSC22 domain family, member 3
Acc ID: CHEBI:28088
Term: genistein
Definition: A 7-hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.
Chemical ID: MESH:D019833
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tsc22d3multiple interactionsISOTSC22D3 (Homo sapiens)6480464CTDESR1 mutant form inhibits the reaction [Genistein inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]]; fulvestrant inhibits the reaction [Genistein inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]]; Genistein inhibits the reaction [Dexamethasone promotes the reaction [NR3C1 protein binds to TSC22D3 promoter]]; Genistein inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 mRNA]; Genistein inhibits the reaction [Dexamethasone results in increased expression of TSC22D3 protein]; Genistein promotes the reaction [ESR1 protein binds to TSC22D3 promoter]PMID:25136773
Go Back to source page   Continue to Ontology report