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GENE - TERM ANNOTATION REPORT

RGD ID: 1550798
Species: Mus musculus
RGD Object: Gene
Symbol: Lgr5
Name: leucine rich repeat containing G protein coupled receptor 5
Acc ID: GO:0007189
Term: adenylate cyclase-activating G protein-coupled receptor signaling pathway
Definition: A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of adenylyl cyclase activity which results in an increase in the intracellular concentration of cyclic AMP (cAMP). This pathway is negatively regulated by phosphodiesterase, which cleaves cAMP and terminates the signaling.
Definition Source(s): GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Lgr5involved_inIBAPANTHER:PTN000689980 or MGI:98849 or FB:FBgn0016650 or MGI:96783 or UniProtKB:Q90674 or UniProtKB:P16473 or Fshr (Rattus norvegicus) or Rxfp1 (Rattus norvegicus) or FB:FBgn0039354 or MGI:21534632290270GO_Central GO_REF:0000033
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