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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550761
Species: Mus musculus
RGD Object: Gene
Symbol: Ccl4
Name: C-C motif chemokine ligand 4
Acc ID: CHEBI:15551
Term: prostaglandin E2
Definition: Prostaglandin F2alpha in which the hydroxy group at position 9 has been oxidised to the corresponding ketone. Prostaglandin E2 is the most common and most biologically potent of mammalian prostaglandins.
Chemical ID: MESH:D015232
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ccl4decreases expressionEXP 6480464CTDDinoprostone results in decreased expression of CCL4 proteinPMID:17667525
Ccl4decreases expressionISOCCL4 (Homo sapiens)6480464CTDDinoprostone results in decreased expression of CCL4 mRNAPMID:16303787
Ccl4multiple interactionsISOCCL4 (Homo sapiens)6480464CTDDinoprostone inhibits the reaction [Indomethacin inhibits the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]]; Dinoprostone promotes the reaction [Roflumilast inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]; Dinoprostone promotes the reaction [roflumilast N-oxide inhibits the reaction [Lipopolysaccharides results in increased secretion of CCL4 protein]]PMID:21913898
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