GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Gsn | increases expression | EXP | | 6480464 | CTD | bisphenol A results in increased expression of GSN mRNA | PMID:30951980 PMID:32156529 PMID:34585602 | Gsn | affects expression | ISO | Gsn (Rattus norvegicus) | 6480464 | CTD | bisphenol A affects the expression of GSN mRNA | PMID:25181051 PMID:32145629 | Gsn | affects expression | ISO | GSN (Homo sapiens) | 6480464 | CTD | bisphenol A affects the expression of GSN mRNA | PMID:30903817 | Gsn | decreases expression | ISO | Gsn (Rattus norvegicus) | 6480464 | CTD | bisphenol A results in decreased expression of GSN mRNA | PMID:30816183 PMID:32528016 PMID:34947998 | Gsn | decreases methylation | ISO | GSN (Homo sapiens) | 6480464 | CTD | bisphenol A results in decreased methylation of GSN gene | PMID:31601247 | Gsn | multiple interactions | ISO | GSN (Homo sapiens) | 6480464 | CTD | [bisphenol A binds to and affects the folding of AR protein] inhibits the reaction [AR protein modified form binds to GSN protein modified form]; [bisphenol A co-treated with Fulvestrant] results in decreased methylation of GSN gene; [bisphenol A results in increased activity of ESR1 protein] which results in decreased expression of GSN mRNA; [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol A] results in increased expression of GSN mRNA; bisphenol A inhibits the reaction [ESR1 protein binds to GSN protein] | PMID:22403704 PMID:28628672 PMID:28751236 PMID:29389661 PMID:31601247 | | ||||||||||||||||||||||
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