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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550218
Species: Mus musculus
RGD Object: Gene
Symbol: Hamp
Name: hepcidin antimicrobial peptide
Acc ID: CHEBI:18248
Term: iron atom
Definition: An iron group element atom that has atomic number 26.
Chemical ID: MESH:D007501
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hampaffects metabolic processingEXP 6480464CTDHAMP protein affects the metabolism of IronPMID:16574947 PMID:17194590
Hampdecreases secretionEXP 6480464CTDHAMP protein results in decreased secretion of IronPMID:16648237
Hampincreases expressionEXP 6480464CTDIron results in increased expression of HAMP mRNAPMID:11113132 PMID:17255318 PMID:22659129
Hampmultiple interactionsEXP 6480464CTD[Acetaminophen results in decreased expression of HAMP mRNA] which results in increased abundance of Iron; [Iron-Dextran Complex results in increased abundance of Iron] which results in increased expression of HAMP mRNA; Iron inhibits the reaction [Diethylnitrosamine results in decreased expression of HAMP mRNA]PMID:19061943 PMID:22610607 PMID:33393188
Hampaffects expressionISOHamp (Rattus norvegicus)6480464CTDIron affects the expression of HAMP mRNAPMID:17116712
Hampdecreases expressionISOHamp (Rattus norvegicus)6480464CTDIron deficiency results in decreased expression of HAMP mRNAPMID:21540277 PMID:22457245
Hampdecreases secretionISOHAMP (Homo sapiens)6480464CTDHAMP protein results in decreased secretion of IronPMID:16460831
Hampincreases expressionISOHamp (Rattus norvegicus)6480464CTDIron results in increased expression of HAMP proteinPMID:22659129
Hampmultiple interactionsISOHAMP (Homo sapiens)6480464CTD[IL6 protein results in increased expression of HAMP protein] which results in decreased secretion of Iron; Iron affects the reaction [HAMP protein results in increased uptake of SLC40A1 protein]PMID:16460831 PMID:20655381
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