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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1550218
Species: Mus musculus
RGD Object: Gene
Symbol: Hamp
Name: hepcidin antimicrobial peptide
Acc ID: CHEBI:16412
Term: lipopolysaccharide
Definition: Liposaccharide natural compounds consisting of a trisaccharide repeating unit (two heptose units and octulosonic acid) with oligosaccharide side chains and 3-hydroxytetradecanoic acid units (they are a major constituent of the cell walls of Gram-negative bacteria).
Chemical ID: MESH:D008070
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Hampincreases expressionEXP 6480464CTDLipopolysaccharides results in increased expression of HAMP mRNAPMID:11113132 PMID:16565419 PMID:16648237 PMID:17255318 PMID:19252488 PMID:21303654
Hampincreases secretionEXP 6480464CTDLipopolysaccharides results in increased secretion of HAMP proteinPMID:24038040
Hampmultiple interactionsEXP 6480464CTDBMP6 gene mutant form inhibits the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]; IL6 protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]; sulforaphane inhibits the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]; TLR4 protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]PMID:17255318 PMID:19252488 PMID:21303654
Hampincreases expressionISOHAMP (Homo sapiens)6480464CTDLipopolysaccharides results in increased expression of HAMP mRNAPMID:21685415
Hampincreases secretionISOHamp (Rattus norvegicus)6480464CTDLipopolysaccharides results in increased secretion of HAMP proteinPMID:24038040
Hampincreases secretionISOHAMP (Homo sapiens)6480464CTDLipopolysaccharides results in increased secretion of HAMP proteinPMID:24038040
Hampmultiple interactionsISOHAMP (Homo sapiens)6480464CTDTNF protein affects the reaction [Lipopolysaccharides results in increased expression of HAMP mRNA]PMID:21685415
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