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GENE - TERM ANNOTATION REPORT

RGD ID: 1550157
Species: Mus musculus
RGD Object: Gene
Symbol: Kras
Name: Kirsten rat sarcoma viral oncogene homolog
Acc ID: DOID:684
Term: hepatocellular carcinoma
Definition: A liver carcinoma that has_material_basis_in undifferentiated hepatocytes and located_in the liver. (DO)
Definition Source(s): http://cancergenome.nih.gov/cancersselected/LiverHepatocellularCarcinoma "DO" "DO", http://en.wikipedia.org/wiki/Hepatocellular_carcinoma "DO" "DO", http://www.omim.org/entry/114550 "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Kras ISOKRAS (Homo sapiens)14398750RGDmRNA,protein:increased expression:liver 
KrasinducedISOKras (Rattus norvegicus)11568697RGDaflatoxin B1 induced:DNA:transversion,transition mutations:cds: 
Kras ISOKRAS (Homo sapiens)11554173CTDCTD Direct Evidence: marker/mechanismPMID:11286481 PMID:11563603
Kras ISOKRAS (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Hepatocellular cancerPMID:12460918 PMID:15696205 PMID:16361624 PMID:16434492 PMID:16618717 PMID:18316791 PMID:18794081 PMID:19075190 PMID:19114683 PMID:19679400 PMID:20921462 PMID:20921465 PMID:21228335 PMID:22407852 PMID:22722830 PMID:2278970 PMID:23325582 PMID:25157968 PMID:26619011 PMID:30891959 PMID:3122217
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