GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Irf3 | affects localization | ISO | IRF3 (Homo sapiens) | 6480464 | CTD | Poly I-C affects the localization of IRF3 protein | PMID:32244040 | Irf3 | increases phosphorylation | ISO | IRF3 (Homo sapiens) | 6480464 | CTD | Poly I-C results in increased phosphorylation of IRF3 protein | PMID:18779317 PMID:36958387 | Irf3 | increases phosphorylation | ISO | Irf3 (Mus musculus) | 6480464 | CTD | Poly I-C results in increased phosphorylation of IRF3 protein | PMID:25780039 PMID:36958387 | Irf3 | multiple interactions | ISO | IRF3 (Homo sapiens) | 6480464 | CTD | [Dronabinol co-treated with Cannabidiol] inhibits the reaction [Poly I-C affects the localization of IRF3 protein]; [Vehicle Emissions analog co-treated with Poly I-C] affects the localization of IRF3 protein; Cannabidiol inhibits the reaction [Poly I-C affects the localization of IRF3 protein]; Dronabinol inhibits the reaction [Poly I-C results in increased localization of IRF3 protein]; TP53 protein affects the reaction [Poly I-C results in increased phosphorylation of IRF3 protein] | PMID:16399790 PMID:18779317 PMID:32244040 | Irf3 | multiple interactions | ISO | Irf3 (Mus musculus) | 6480464 | CTD | APPL1 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; BX795 inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; chrysin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; DNM2 protein promotes the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; eriodictyol inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; Quercetin inhibits the reaction [Poly I-C results in increased expression of IRF3 mRNA]; Sodium Selenite inhibits the reaction [Poly I-C results in increased activity of IRF3 protein] | PMID:18279804 PMID:19426678 PMID:25780039 | | ||||||||||||||||||||||
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