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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1549771
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ugt1a9
Name: UDP glucuronosyltransferase family 1 member A9
Acc ID: CHEBI:4798
Term: entacapone
Definition: A monocarboxylic acid amide that is N,N-diethylprop-2-enamide in which the hydrogen at position 2 is substituted by a cyano group and the hydrogen at the 3E position is substituted by a 3,4-dihydroxy-5-nitrophenyl group.
Chemical ID: MESH:C071192
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ugt1a9decreases glucuronidationISOUGT1A9 (Homo sapiens)6480464CTDUGT1A9 protein mutant form results in decreased glucuronidation of entacaponePMID:16344532
Ugt1a9increases glucuronidationISOUGT1A9 (Homo sapiens)6480464CTDUGT1A9 protein results in increased glucuronidation of entacaponePMID:15044611 PMID:15802387 PMID:16344532
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