Gene Term Annotation Report - Rat Genome Database

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GENE - TERM ANNOTATION REPORT

RGD ID:	14294839
Species:	Sus scrofa
RGD Object:	Gene
Symbol:	ACHE
Name:	acetylcholinesterase

Acc ID:	GO:0045202
Term:	synapse
Definition:	The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.
Definition Source(s):	GOC:aruk, ISBN:0198506732, PMID:24619342, PMID:29383328, PMID:31998110

Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.

Object Symbol	Qualifier	Evidence	With	Reference	Source	Notes	Original Reference(s)
ACHE	located_in	IEA	UniProtKB:P21836 or UniProtKB:P22303 or ensembl:ENSMUSP00000024099 or ensembl:ENSP00000241069	150520179	Ensembl		GO_REF:0000107
ACHE	located_in	IEA	UniProtKB-KW:KW-0770	150520179	UniProt		GO_REF:0000043
ACHE	located_in	IEA	UniProtKB-SubCell:SL-0258	150520179	UniProt		GO_REF:0000044

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