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GENE - TERM ANNOTATION REPORT

RGD ID: 14244462
Species: Sus scrofa
RGD Object: Gene
Symbol: CXCL8
Name: C-X-C motif chemokine ligand 8
Acc ID: DOID:9008114
Term: Helicobacter Infections
Definition: Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.
Definition Source(s): MESH:D016481
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL8 ISOCxcl15 (Mus musculus)9068941RGDassociated with gastritis;mRNA:increased expression:stomach (mouse, Helicobacter felis)PMID:17242461 REF_RGD_ID:38549339
CXCL8disease_progressionISOCxcl15 (Mus musculus)9068941RGDmRNA:altered expression:gastric antrum (mouse)PMID:29085807 REF_RGD_ID:38549349
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