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GENE - TERM ANNOTATION REPORT

RGD ID: 14234957
Species: Sus scrofa
RGD Object: Gene
Symbol: SOAT1
Name: sterol O-acyltransferase 1
Acc ID: PW:0000728
Term: statin pharmacodynamics pathway
Definition: The pathway of statins-target interaction and of the biochemical or physiological responses to drug. Statins are a class of drugs used to lower cholesterol. They act as inhibitors of HMG-CoA reductase, the enzyme that catalyzes an early rate-limiting step in cholesterol biosynthesis. Genetic variations can cause differences in the response of the organism to the drug.
Definition Source(s): http://www.pharmgkb.org/ "PharmGKB" "PharmGKB"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SOAT1 ISOSOAT1 (Homo sapiens)9068941SMPDB SMP:00082 SMP:00089 SMP:00092 SMP:00099 SMP:00111 SMP:00119 SMP:00131
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