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GENE - TERM ANNOTATION REPORT

RGD ID: 14187349
Species: Sus scrofa
RGD Object: Gene
Symbol: CASP8
Name: caspase 8
Acc ID: GO:0097199
Term: cysteine-type endopeptidase activity involved in apoptotic signaling pathway
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.
Definition Source(s): GOC:mtg_apoptosis, PMID:11717445, Wikipedia:Caspase
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP8 IBAPANTHER:PTN000047948, UniProtKB:Q14790, UniProtKB:Q9285114298760GO_Central (PMID:21873635)

PMID:21873635
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.