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GENE - TERM ANNOTATION REPORT

RGD ID: 14180349
Species: Sus scrofa
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: DOID:9003936
Term: Cardiomegaly
Definition: Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.
Definition Source(s): MESH:D006332
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3 ISONos3 (Rattus norvegicus)9068941RGDprotein:increased expression:aortaPMID:17487232 REF_RGD_ID:2289120
NOS3treatmentISONos3 (Rattus norvegicus)9068941RGD PMID:29331788 REF_RGD_ID:13504707
NOS3 ISONOS3 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanism|therapeuticPMID:11504159 PMID:12224825 PMID:16844920 PMID:17487232
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