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GENE - TERM ANNOTATION REPORT

RGD ID: 14180349
Species: Sus scrofa
RGD Object: Gene
Symbol: NOS3
Name: nitric oxide synthase 3
Acc ID: DOID:8947
Term: diabetic retinopathy
Definition: Disease of the RETINA as a complication of DIABETES MELLITUS. It is characterized by the progressive microvascular complications, such as ANEURYSM, interretinal EDEMA, and intraocular PATHOLOGIC NEOVASCULARIZATION.
Definition Source(s): MESH:D003930
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS3 ISONos3 (Rattus norvegicus)9068941RGDassociated with Diabetes Mellitus, Experimental;mRNA:decreased expression:retina (rat)PMID:23059402 REF_RGD_ID:7771569
NOS3 ISONOS3 (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 1;DNA:duplication:intron:IVS4?-?+27 (human)PMID:11918626 REF_RGD_ID:7421532
NOS3 ISONOS3 (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:snps, duplication, haplotype:promoter, cds, intron:g.-786T>C, p.E298N, IVS4?-?+27 (human)PMID:17973941 REF_RGD_ID:7421533
NOS3no_associationISONOS3 (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:duplication:intron:IVS4?-?+27 (human)PMID:16581274 PMID:17558849 REF_RGD_ID:7421531 REF_RGD_ID:7775042
NOS3no_associationISONOS3 (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:snps, duplication, haplotype:promoter, cds, intron:g.-786T>C, p.E298N, IVS4?-?+27 (human)PMID:22017289 REF_RGD_ID:7777101
NOS3onsetISONOS3 (Homo sapiens)9068941RGDDNA:snps:promoter, exon:c.-786T>C, c.774C>T (human)PMID:15890549 REF_RGD_ID:7771565
NOS3severityISONos3 (Mus musculus)9068941RGDassociated with Diabetes Mellitus, ExperimentalPMID:20435587 REF_RGD_ID:7771568
NOS3susceptibilityISONOS3 (Homo sapiens)9068941RGDassociated with Diabetes Mellitus, Type 2;DNA:snp:exon:c.894G>T (human)PMID:23776381 REF_RGD_ID:7777103
NOS3treatmentISONos3 (Rattus norvegicus)9068941RGDassociated with Diabetes Mellitus, ExperimentalPMID:18840783 REF_RGD_ID:7771606
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