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GENE - TERM ANNOTATION REPORT

RGD ID: 14173345
Species: Sus scrofa
RGD Object: Gene
Symbol: STAT1
Name: signal transducer and activator of transcription 1
Acc ID: DOID:9563
Term: bronchiectasis
Definition: A bronchial disease that is a chronic inflammatory condition of one or more bronchi or bronchioles marked by dilatation and loss of elasticity of the walls resulting from damage to the airway wall leading to the formation of small sacs on the bronchial wall and impairment of cilia mobility in the lung. Inflammation of the bronchial wall increases mucus secretion which serves as a breeding ground for bacteria. Bronchiectasis is caused by repeated respiratory infections, immune deficiency disorders, hereditary disorders (cystic fibrosis or primary ciliary dyskinesia), mechanical factors (inhaled object or a lung tumor) or inhaling toxic substances. (DO)
Definition Source(s): http://www.merck.com/mmhe/sec04/ch047/ch047a.html "DO" "DO", http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=bronchiectasis "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
STAT1 ISOSTAT1 (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: BronchiectasisPMID:22730530 PMID:23534974 PMID:23541320 PMID:23709754 PMID:24239102 PMID:25042743 PMID:25741868 PMID:26604104 PMID:26743090 PMID:27379765 PMID:27577878 PMID:28492532 PMID:28597685
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