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GENE - TERM ANNOTATION REPORT

RGD ID: 14134172
Species: Sus scrofa
RGD Object: Gene
Symbol: CASP3
Name: caspase 3
Acc ID: DOID:9004484
Term: Sepsis
Definition: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Definition Source(s): MESH:D018805
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP3treatmentISOCasp3 (Rattus norvegicus)9068941RGD PMID:29180187 REF_RGD_ID:13782295
CASP3 ISOCASP3 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:16003065 PMID:32062619
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