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GENE - TERM ANNOTATION REPORT

RGD ID: 14098222
Species: Sus scrofa
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: DOID:9004484
Term: Sepsis
Definition: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Definition Source(s): MESH:D018805
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6 ISOIl6 (Rattus norvegicus)9068941RGD PMID:27598601 REF_RGD_ID:14975121
IL6 ISOIl6 (Rattus norvegicus)9068941RGDassociated with Diabetes Mellitus, Non-Insulin-Dependent; mRNA, protein:increased expression:liver, extracellular space (rat)PMID:19079684 REF_RGD_ID:2307280
IL6treatmentISOIl6 (Rattus norvegicus)9068941RGD PMID:25317848 REF_RGD_ID:11062009
IL6 ISOIL6 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:32062619
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