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GENE - TERM ANNOTATION REPORT

RGD ID: 14098222
Species: Sus scrofa
RGD Object: Gene
Symbol: IL6
Name: interleukin 6
Acc ID: DOID:1596
Term: depressive disorder
Definition: A mood disorder characterized by persistent sadness, emptiness, or irritability and decreased ability to function. (DO)
Definition Source(s): https://my.clevelandclinic.org/health/diseases/9290-depression "DO" "DO", https://pubmed.ncbi.nlm.nih.gov/31550874/ "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL6 ISOIl6 (Mus musculus)9068941RGDprotein:increased expression:serum, hippocampus (mouse)PMID:31396300 REF_RGD_ID:126908003
IL6 ISOIL6 (Homo sapiens)9068941RGDassociated with Chronic Hepatitis C; DNA:insertion/deletion:promoter:PMID:23571152 REF_RGD_ID:38676480
IL6 ISOIL6 (Homo sapiens)9068941RGDassociated with gastric adenocarcinoma; protein:increased expression:blood serum (human)PMID:31396300 REF_RGD_ID:126908003
IL6 ISOIl6 (Rattus norvegicus)9068941RGDmRNA:increased expression:colonPMID:23589140 REF_RGD_ID:10402829
IL6 ISOIl6 (Rattus norvegicus)9068941RGDprotein:increased expression:hippocampus (rat)PMID:27106565 REF_RGD_ID:11062144
IL6treatmentISOIL6 (Homo sapiens)9068941RGDassociated with Hepatitis C, Chronic;DNA:SNP:promoter:-174G>C (human)PMID:28083615 REF_RGD_ID:14975286
IL6 ISOIL6 (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:18458677
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