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GENE - TERM ANNOTATION REPORT

RGD ID: 14040283
Species: Sus scrofa
RGD Object: Gene
Symbol: CACNA1A
Name: calcium voltage-gated channel subunit alpha1 A
Acc ID: GO:0007268
Term: chemical synaptic transmission
Definition: The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse.
Definition Source(s): GOC:jl, MeSH:D009435
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CACNA1A ISOCacna1a (Rattus norvegicus)9068941RGD PMID:14673106 REF_RGD_ID:1358385
CACNA1Aacts_upstream_of_or_withinISOMGI:1856209 or MGI:18562119068941MGI PMID:12040045

PMID:12040045
CACNA1Aacts_upstream_of_or_withinISOMGI:21813849068941MGI PMID:10611370 PMID:15548652

PMID:10611370 PMID:15548652
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