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GENE - TERM ANNOTATION REPORT

RGD ID: 14038749
Species: Sus scrofa
RGD Object: Gene
Symbol: NOS2
Name: nitric oxide synthase 2
Acc ID: DOID:11339
Term: pneumocystosis
Definition: An opportunistic mycosis that is located in lungs, but can also occur in eyes, ears, skin, thyroid, pituitary, palate, parathyroid, esophagus, pleura, heart, liver, spleen, small intestine, adrenals, kidneys, bone marrow, and lymph nodes, has_material_basis_in Pneumocystis jirovecii that effects interstitial and alveolar tissues and has symptom nonproductive cough, has symptom shortness of breath, and has symptom fever. (DO)
Definition Source(s): http://www.nlm.nih.gov/medlineplus/ency/article/000671.htm "DO" "DO", http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=pneumocystis%20carinii%20pneumonia "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NOS2 ISONos2 (Rattus norvegicus)9068941RGDmRNA:increased expression:alveolar macrophagePMID:20377877 REF_RGD_ID:4144112
NOS2 ISONos2 (Rattus norvegicus)9068941RGDprotein:decreased dimerization:alveolar macrophagePMID:20558778 REF_RGD_ID:4891486
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