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GENE - TERM ANNOTATION REPORT

RGD ID: 14001478
Species: Sus scrofa
RGD Object: Gene
Symbol: MRE11
Name: MRE11 homolog, double strand break repair nuclease
Acc ID: GO:0006303
Term: double-strand break repair via nonhomologous end joining
Definition: The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
Definition Source(s): GOC:rph, PMID:10827453, PMID:24837021
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MRE11involved_inIEAUniProtKB:P49959 or ensembl:ENSP00000325863150520179Ensembl GO_REF:0000107
MRE11involved_inIBAPANTHER:PTN000015644 or PomBase:SPAC13C5.07 or SGD:S000004837 or UniProtKB:P49959150520179GO_Central GO_REF:0000033
MRE11involved_inIEAPANTHER:PTHR10139:SF1150520179TreeGrafter GO_REF:0000118
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