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RGD ID: 13998579
Species: Sus scrofa
RGD Object: Gene
Symbol: FRZB
Name: frizzled related protein
Acc ID: GO:0090090
Term: negative regulation of canonical Wnt signaling pathway
Definition: Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.
Definition Source(s): GOC:dph, GOC:tb
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FRZB IBAMGI:MGI:892010, MGI:MGI:892032, PANTHER:PTN000885362, RGD:621075, UniProtKB:Q6FHJ7, UniProtKB:Q9276514298760GO_Central (PMID:21873635)

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.