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GENE - TERM ANNOTATION REPORT

RGD ID: 13933940
Species: Sus scrofa
RGD Object: Gene
Symbol: ACE
Name: angiotensin I converting enzyme (peptidyl-dipeptidase A) 1
Acc ID: DOID:0060224
Term: atrial fibrillation
Definition: A heart conduction disease that is characterized by uncoordinated electrical activity in the heart's upper chambers (the atria), which causes the heartbeat to become fast and irregular and has symptoms palpitations, weakness, fatigue, lightheadedness, dizziness, confusion, shortness of breath and chest pain. (DO)
Definition Source(s): http://en.wikipedia.org/wiki/Atrial_fibrillation "DO" "DO", http://www.mayoclinic.org/diseases-conditions/atrial-fibrillation/basics/definition/con-20027014 "DO" "DO", http://www.nhlbi.nih.gov/health/health-topics/topics/af "DO" "DO"
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACEsusceptibilityISOACE (Homo sapiens)9068941RGDDNA:deletion:intron:IVS16+1464-1751del (human)PMID:19648063 PMID:23170137 REF_RGD_ID:7829797 REF_RGD_ID:8142351
ACE ISOACE (Homo sapiens)9068941CTDCTD Direct Evidence: marker/mechanismPMID:15331425
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