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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 13915338
Species: Sus scrofa
RGD Object: Gene
Symbol: EDN1
Name: endothelin 1
Acc ID: CHEBI:3750
Term: clofibrate
Definition: The ethyl ester of clofibric acid.
Chemical ID: MESH:D002994
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
EDN1decreases expressionEXP 6480464CTDClofibrate results in decreased expression of EDN1 proteinPMID:17105827
EDN1multiple interactionsEXP 6480464CTDClofibrate inhibits the reaction [AGT protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [KNG1 protein modified form results in increased expression of EDN1 protein]; Clofibrate inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of EDN1 protein]; Nitric Oxide deficiency inhibits the reaction [Clofibrate results in decreased expression of EDN1 protein]PMID:17105827
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