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GENE - TERM ANNOTATION REPORT

RGD ID: 13885278
Species: Sus scrofa
RGD Object: Gene
Symbol: CASP9
Name: caspase 9
Acc ID: GO:0006915
Term: apoptotic process
Definition: A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.
Definition Source(s): GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CASP9involved_inIEAUniProtKB:P55211 or UniProtKB:Q8C3Q9 or ensembl:ENSMUSP00000030747 or ensembl:ENSP00000330237150520179Ensembl GO_REF:0000107
CASP9acts_upstream_of_or_withinISOCasp9 (Mus musculus)9068941MGI MGI:3615714 PMID:16469926

MGI:3615714 PMID:16469926
CASP9involved_inIEAUniProtKB-KW:KW-0053150520179UniProt GO_REF:0000043
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