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RGD ID: 13874983
Species: Sus scrofa
RGD Object: Gene
Symbol: FBXL22
Name: F-box and leucine rich repeat protein 22
Acc ID: GO:0019005
Term: SCF ubiquitin ligase complex
Definition: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Definition Source(s): PMID:15571813, PMID:15688063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FBXL22 IBAFB:FBgn0037236, MGI:MGI:1351663, MGI:MGI:2442921, PANTHER:PTN001923412, RGD:1311830, TAIR:locus:2061136, TAIR:locus:2099237, TAIR:locus:2174398, UniProtKB:Q13309, UniProtKB:Q9UKT714298760GO_Central (PMID:21873635)

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.