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GENE - TERM ANNOTATION REPORT

RGD ID: 13854425
Species: Sus scrofa
RGD Object: Gene
Symbol: IL1RN
Name: interleukin 1 receptor antagonist
Acc ID: DOID:824
Term: periodontitis
Definition: Inflammation and loss of connective tissues supporting or surrounding the teeth. This may involve any part of the PERIODONTIUM. Periodontitis is currently classified by disease progression (CHRONIC PERIODONTITIS; AGGRESSIVE PERIODONTITIS) instead of age of onset. (From 1999 International Workshop for a Classification of Periodontal Diseases and Conditions, American Academy of Periodontology)
Definition Source(s): MESH:D010518
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1RN ISOIL1RN (Homo sapiens)9068941RGDmRNA:increased expression:gingivaPMID:22795294 REF_RGD_ID:6906881
IL1RNsusceptibilityISOIL1RN (Homo sapiens)9068941RGDassociated with Kidney Failure, Chronic;DNA:repeats:intron:IVS2+914_1000dup IL1RN*2 (human)PMID:22795294 REF_RGD_ID:6906881
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