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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359580
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Atg5
Name: autophagy related 5
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Atg5affects response to substanceISOATG5 (Homo sapiens)6480464CTDATG5 protein affects the susceptibility to resveratrolPMID:23680031
Atg5increases expressionISOATG5 (Homo sapiens)6480464CTDresveratrol results in increased expression of ATG5 mRNAPMID:12002526 PMID:12569576 PMID:23680031
Atg5increases expressionISOAtg5 (Mus musculus)6480464CTDresveratrol results in increased expression of ATG5 mRNAPMID:24095927
Atg5multiple interactionsISOATG5 (Homo sapiens)6480464CTDATG5 protein affects the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; ATG5 protein affects the reaction [Resveratrol affects the metabolism of MAP1LC3B protein]; ATG5 protein affects the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; ATG5 protein affects the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; ATG5 protein affects the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; ATG5 protein promotes the reaction [Resveratrol inhibits the reaction [Palmitic Acid results in increased expression of SREBF1 protein]]; Resveratrol inhibits the reaction [Particulate Matter results in increased expression of ATG5 mRNA]; Resveratrol inhibits the reaction [Particulate Matter results in increased expression of ATG5 protein]; Sirolimus inhibits the reaction [Resveratrol inhibits the reaction [Particulate Matter results in increased expression of ATG5 protein]]PMID:23680031 PMID:24145604 PMID:25943029 PMID:29781141
Atg5multiple interactionsISOAtg5 (Mus musculus)6480464CTDresveratrol promotes the reaction [Ethanol results in increased expression of ATG5 mRNA]PMID:24095927
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