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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359360
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Mef2a
Name: myocyte enhancer factor 2a
Acc ID: CHEBI:27732
Term: caffeine
Definition: A trimethylxanthine in which the three methyl groups are located at positions 1, 3, and 7. A purine alkaloid that occurs naturally in tea and coffee.
Chemical ID: MESH:D002110
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
increases expressionEXP 6480464CTDCaffeine results in increased expression of MEF2A mRNA

Caffeine results in increased expression of MEF2A protein

PMID:25093688
multiple interactionsEXP 6480464CTDDantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A mRNA]

Dantrolene inhibits the reaction [Caffeine results in increased expression of MEF2A protein]

PMID:25093688
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.