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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359311
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Tsku
Name: tsukushi, small leucine rich proteoglycan
Acc ID: CHEBI:16469
Term: 17beta-estradiol
Definition: The 17beta-isomer of estradiol.
Chemical ID: MESH:D004958
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Tskuaffects expressionEXP 6480464CTDEstradiol affects the expression of TSKU mRNAPMID:32145629
Tskudecreases expressionEXP 6480464CTDEstradiol results in decreased expression of TSKU mRNAPMID:35192832
Tskuincreases expressionISOTSKU (Homo sapiens)6480464CTDEstradiol results in increased expression of TSKU mRNAPMID:14605097 PMID:21185374 PMID:22071320 PMID:23019147 PMID:24758408
Tskumultiple interactionsISOTSKU (Homo sapiens)6480464CTD[Estradiol promotes the reaction [NRIP1 protein binds to TSKU promoter]] which results in decreased expression of TSKU mRNA; AHR protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TSKU promoter]]; AHR protein inhibits the reaction [Estradiol results in increased expression of TSKU mRNA]; EGF protein inhibits the reaction [Estradiol results in increased expression of TSKU mRNA]; ESR1 protein affects the reaction [Estradiol promotes the reaction [NRIP1 protein binds to TSKU promoter]]; Estradiol promotes the reaction [[ESR1 protein binds to AHR protein binds to NRIP1 protein] which binds to TSKU promoter]; Estradiol promotes the reaction [AHR protein binds to TSKU promoter]; Estradiol promotes the reaction [ESR1 protein binds to TSKU promoter]; Estradiol promotes the reaction [NRIP1 protein binds to TSKU promoter]PMID:22071320 PMID:24758408
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