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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359266
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Pmaip1
Name: phorbol-12-myristate-13-acetate-induced protein 1
Acc ID: CHEBI:7959
Term: D-penicillamine
Definition: An optically active form of penicillamine having D-configuration. Pharmaceutical form (L-form is toxic) of chelating agent used to treat heavy metal poisoning.
Chemical ID: MESH:D010396
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Pmaip1increases expressionISOPMAIP1 (Homo sapiens)6480464CTDPenicillamine results in increased expression of PMAIP1 mRNA; Penicillamine results in increased expression of PMAIP1 proteinPMID:22843330
Pmaip1multiple interactionsISOPMAIP1 (Homo sapiens)6480464CTDPMAIP1 mutant form inhibits the reaction [Penicillamine results in decreased expression of MCL1 protein]PMID:22843330
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