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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359136
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Ints12
Name: integrator complex subunit 12
Acc ID: CHEBI:6402
Term: leflunomide
Definition: A monocarboxylic acid amide obtained by formal condensation of the carboxy group of 5-methyl-1,2-oxazole-4-carboxylic acid with the anilino group of 4-(trifluoromethyl)aniline. The prodrug of teriflunomide.
Chemical ID: MESH:C045463
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ints12decreases expressionISOInts12 (Mus musculus)6480464CTDleflunomide results in decreased expression of INTS12 mRNAPMID:19751817
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