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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1359092
Species: Rattus norvegicus
RGD Object: Gene
Symbol: Krt10
Name: keratin 10
Acc ID: CHEBI:15367
Term: all-trans-retinoic acid
Definition: A retinoic acid in which all four exocyclic double bonds have E- (trans-) geometry.
Chemical ID: MESH:D014212
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
QualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
decreases expressionISORGD:13543946480464CTDTretinoin results in decreased expression of KRT10 mRNA

PMID:15982314, PMID:16985168
decreases expressionISORGD:15504846480464CTDTretinoin results in decreased expression of KRT10 mRNA

PMID:10748128
increases expressionISORGD:13543946480464CTDTretinoin metabolite results in increased expression of KRT10 mRNA, Tretinoin results in increased expression of KRT10 mRNA, Tretinoin results in increased expression of KRT10 protein

PMID:15982314, PMID:9716179
multiple interactionsISORGD:15504846480464CTDTretinoin promotes the reaction [RARA gene mutant form results in decreased expression of KRT10 mRNA]

PMID:10748128
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.