GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | DNMT1 | affects response to substance | EXP | | 6480464 | CTD | DNMT1 protein affects the susceptibility to Decitabine | PMID:17991895 | DNMT1 | decreases expression | EXP | | 6480464 | CTD | Decitabine results in decreased expression of DNMT1 mRNA; Decitabine results in decreased expression of DNMT1 protein | PMID:16613325 PMID:17571247 PMID:17616700 PMID:17621267 PMID:17653094 PMID:17991895 PMID:18676679 PMID:19117987 PMID:19221000 PMID:19470736 PMID:19732952 PMID:19840838 PMID:21078381 PMID:21771726 PMID:21801466 PMID:22749965 | DNMT1 | increases degradation | EXP | | 6480464 | CTD | Decitabine results in increased degradation of DNMT1 protein | PMID:19417133 | DNMT1 | increases expression | EXP | | 6480464 | CTD | Decitabine results in increased expression of DNMT1 mRNA | PMID:19117987 | DNMT1 | multiple interactions | EXP | | 6480464 | CTD | [Decitabine co-treated with sodium arsenite] results in decreased expression of DNMT1 protein; Decitabine affects the reaction [PARP1 protein affects the expression of DNMT1 mRNA]; Decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [Cadmium Chloride results in increased expression of DNMT1 protein]; Decitabine inhibits the reaction [sodium arsenite results in increased expression of DNMT1 protein]; Decitabine promotes the reaction [sodium arsenite results in decreased expression of DNMT1 protein]; DNMT1 protein affects the reaction [Decitabine results in increased expression of H2AX protein]; IL6 protein inhibits the reaction [Decitabine results in decreased expression of DNMT1 mRNA] | PMID:17621267 PMID:17991895 PMID:22112500 PMID:26409248 PMID:32006662 PMID:32905139 PMID:35850069 | DNMT1 | affects response to substance | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | DNMT1 affects the susceptibility to Decitabine | PMID:14581508 | DNMT1 | decreases activity | ISO | Dnmt1 (Rattus norvegicus) | 6480464 | CTD | Decitabine results in decreased activity of DNMT1 protein | PMID:21449042 | DNMT1 | decreases expression | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | Decitabine results in decreased expression of DNMT1 protein | PMID:19222872 PMID:19679824 | DNMT1 | decreases expression | ISO | Dnmt1 (Rattus norvegicus) | 6480464 | CTD | Decitabine results in decreased expression of DNMT1 protein | PMID:23423710 | DNMT1 | multiple interactions | ISO | Dnmt1 (Mus musculus) | 6480464 | CTD | Decitabine inhibits the reaction [Particulate Matter promotes the reaction [[ovalbumin-alum co-treated with Ovalbumin] results in increased expression of DNMT1 protein]]; Decitabine inhibits the reaction [Particulate Matter results in increased expression of DNMT1 protein] | PMID:30481581 | DNMT1 | multiple interactions | ISO | Dnmt1 (Rattus norvegicus) | 6480464 | CTD | Decitabine inhibits the reaction [Dust results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [Dust results in increased expression of DNMT1 protein]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of DNMT1 mRNA]; Decitabine inhibits the reaction [TGFB1 protein results in increased expression of DNMT1 protein] | PMID:24211420 PMID:30815999 | | ||||||||||||||||||||||
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