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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1354178
Species: Homo sapiens
RGD Object: Gene
Symbol: DNMT1
Name: DNA methyltransferase 1
Acc ID: CHEBI:34372
Term: 4,4'-sulfonyldiphenol
Definition: A sulfone that is diphenyl sulfone in which both of the para hydrogens have been replaced by hydroxy groups.
Chemical ID: MESH:C543008
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DNMT1increases expressionEXP 6480464CTDbisphenol S results in increased expression of DNMT1 mRNA; bisphenol S results in increased expression of DNMT1 proteinPMID:31601247 PMID:32105160
DNMT1multiple interactionsEXP 6480464CTDbisphenol S promotes the reaction [ESR1 protein binds to DNMT1 promoter]; DNMT1 protein promotes the reaction [bisphenol S results in decreased abundance of 5-hydroxymethylcytosine]; DNMT1 protein promotes the reaction [bisphenol S results in decreased expression of TET2 protein]; DNMT1 protein promotes the reaction [bisphenol S results in increased methylation of TET2 promoter]; ESR1 protein promotes the reaction [bisphenol S results in increased expression of DNMT1 mRNA]; ESR1 protein promotes the reaction [bisphenol S results in increased expression of DNMT1 protein]PMID:32105160
DNMT1increases expressionISODnmt1 (Mus musculus)6480464CTDbisphenol S results in increased expression of DNMT1 mRNAPMID:29741722
DNMT1multiple interactionsISODnmt1 (Rattus norvegicus)6480464CTD[bisphenol A co-treated with bisphenol F co-treated with bisphenol S] results in decreased expression of DNMT1 mRNAPMID:36041667
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