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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353901
Species: Homo sapiens
RGD Object: Gene
Symbol: AKR1C2
Name: aldo-keto reductase family 1 member C2
Acc ID: CHEBI:29865
Term: benzo[a]pyrene
Definition: An ortho- and peri-fused polycyclic arene consisting of five fused benzene rings.
Chemical ID: MESH:D001564
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
AKR1C2affects methylationEXP 6480464CTDBenzo(a)pyrene affects the methylation of AKR1C2 promoterPMID:27901495
AKR1C2affects response to substanceEXP 6480464CTDAKR1C2 protein affects the susceptibility to Benzo(a)pyrenePMID:19800895
AKR1C2increases expressionEXP 6480464CTDBenzo(a)pyrene results in increased expression of AKR1C2 mRNAPMID:15735009 PMID:16545412 PMID:19800895 PMID:20106945 PMID:21632981 PMID:26198647
AKR1C2multiple interactionsEXP 6480464CTD[Particulate Matter co-treated with Benzo(a)pyrene] results in increased expression of AKR1C2 mRNA; [Vehicle Emissions co-treated with Benzo(a)pyrene] results in increased expression of AKR1C2 mRNA; AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with Methyl Parathion]; AKR1C2 protein affects the susceptibility to [Benzo(a)pyrene co-treated with methylparaoxon]; Benzo(a)pyrene promotes the reaction [Methyl Parathion results in increased activity of AKR1C2 protein]; Methyl Parathion promotes the reaction [Benzo(a)pyrene results in increased expression of AKR1C2 mRNA]PMID:17612574 PMID:19800895
AKR1C2multiple interactionsISOAkr1c21 (Mus musculus)6480464CTD[Tetradecanoylphorbol Acetate co-treated with Benzo(a)pyrene co-treated with Particulate Matter] results in increased expression of AKR1C21 mRNAPMID:18353537
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