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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353629
Species: Homo sapiens
RGD Object: Gene
Symbol: IL12B
Name: interleukin 12B
Acc ID: CHEBI:30052
Term: copper(0)
Definition: An elemental copper that has formula Cu.
Chemical ID: MESH:D003300
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL12Bincreases secretionISOIl12b (Mus musculus)6480464CTDCopper results in increased secretion of IL12B proteinPMID:19635393
IL12Bmultiple interactionsISOIl12b (Mus musculus)6480464CTD[Aluminum co-treated with Copper] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL12B mRNA]; [ATP7A gene mutant form results in increased abundance of Copper] which results in increased expression of IL12B mRNAPMID:15467011 PMID:23690655
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