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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353629
Species: Homo sapiens
RGD Object: Gene
Symbol: IL12B
Name: interleukin 12B
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL12Baffects secretionISOIl12b (Mus musculus)6480464CTDEthanol affects the secretion of IL12B proteinPMID:20624996
IL12Bmultiple interactionsISOIl12b (Mus musculus)6480464CTDEthanol inhibits the reaction [Lipopolysaccharides results in increased expression of [IL12A protein binds to IL12B protein]]; Ethanol inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B mRNA]; Ethanol inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein]; Ethanol inhibits the reaction [Poly I-C results in increased expression of IL12B protein]PMID:10798593 PMID:19500611
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