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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1353417
Species: Homo sapiens
RGD Object: Gene
Symbol: XIAP
Name: X-linked inhibitor of apoptosis
Acc ID: CHEBI:75142
Term: N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal
Definition: A tripeptide that is L-leucyl-L-leucyl-L-leucine in which the C-terminal carboxy group has been reduced to the corresponding aldehyde and the N-terminal amino group is protected as its benzyloxycarbonyl derivative.
Chemical ID: MESH:C072553
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
XIAPincreases cleavageEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased cleavage of XIAP proteinPMID:16287099
XIAPincreases ubiquitinationEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of XIAP proteinPMID:31699976
XIAPmultiple interactionsEXP 6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[pifithrin co-treated with Topotecan] results in increased degradation of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cannabidiol promotes the reaction [DIABLO protein binds to XIAP protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Cannabidiol results in decreased expression of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [diallyl trisulfide results in decreased expression of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [sodium arsenite results in decreased expression of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [Cannabidiol results in increased ubiquitination of XIAP protein]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde promotes the reaction [trimethyltin chloride results in decreased expression of XIAP protein]; Cannabidiol promotes the reaction [benzyloxycarbonylleucyl-leucyl-leucine aldehyde results in increased ubiquitination of XIAP protein]PMID:19812371 PMID:21411500 PMID:22627131 PMID:23423712 PMID:31699976
XIAPmultiple interactionsISOXiap (Mus musculus)6480464CTDbenzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Topotecan results in increased degradation of XIAP protein]PMID:19812371
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