Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - TERM ANNOTATION REPORT

RGD ID: 1353257
Species: Homo sapiens
RGD Object: Gene
Symbol: WNT5A
Name: Wnt family member 5A
Acc ID: GO:0060071
Term: Wnt signaling pathway, planar cell polarity pathway
Definition: A type of non-canonical Wnt signaling pathway in which Wnt binding to its receptor on the surface of a target cell results in the activation small G proteins such as Rho, Rac, and Cdc42 which, in turn activate effectors, including C-Jun N-terminal kinase (JNK) and Rho kinase (Rok). The signaling ends with change in the transcription of target genes and/or reorganisation of the cytoskeleton.
Definition Source(s): PMID:11532397, PMID:25349257, PMID:28293032, PMID:37804416
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
WNT5Ainvolved_inIEAUniProtKB:P22725 or ensembl:ENSMUSP00000064878150520179Ensembl GO_REF:0000107
WNT5Aacts_upstream_of_or_withinISOMGI:18576179068941MGI PMID:17433286 PMID:19300477

PMID:17433286 PMID:19300477
WNT5Aacts_upstream_of_or_withinISOMGI:21352729068941MGI PMID:17433286

PMID:17433286
WNT5Aacts_upstream_of_or_withinISOMGI:978459068941MGI PMID:18953410

PMID:18953410
WNT5Aacts_upstream_of_or_withinISOWnt5a (Rattus norvegicus)9068941MGIPMID:15537637

PMID:15537637 REF_RGD_ID:8554067
WNT5Aacts_upstream_of_or_withinISOWnt5a (Mus musculus)9068941MGI PMID:19056682

PMID:19056682
WNT5Ainvolved_inISSUniProtKB:P22725150520179ParkinsonsUK-UCL GO_REF:0000024
WNT5Ainvolved_inTAS 150520179ParkinsonsUK-UCL PMID:22988876 PMID:23517308 PMID:24431302

PMID:22988876 PMID:23517308 PMID:24431302
Go Back to source page   Continue to Ontology report