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GENE - TERM ANNOTATION REPORT

RGD ID: 1353256
Species: Homo sapiens
RGD Object: Gene
Symbol: F2
Name: coagulation factor II, thrombin
Acc ID: GO:0004252
Term: serine-type endopeptidase activity
Definition: Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine).
Definition Source(s): GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F2enablesIDA 150520179BHF-UCL PMID:12855810 PMID:1672265

PMID:12855810 PMID:1672265
F2enablesIEAUniProtKB:P19221 or ensembl:ENSMUSP00000028681150520179Ensembl GO_REF:0000107
F2enablesIBAMGI:88380 or PANTHER:PTN002799255 or UniProtKB:P00734 or UniProtKB:P00735150520179GO_Central GO_REF:0000033
F2enablesIEAInterPro:IPR001254 or InterPro:IPR003966 or InterPro:IPR018114 or InterPro:IPR018992 or InterPro:IPR037111150520179InterPro GO_REF:0000002
F2enablesIEAEC:3.4.21.5150520179UniProt GO_REF:0000003
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