GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | XBP1 | increases splicing | EXP | | 6480464 | CTD | Acetylcysteine results in increased splicing of XBP1 mRNA | PMID:19722195 | XBP1 | multiple interactions | EXP | | 6480464 | CTD | Acetylcysteine inhibits the reaction [Ethylmercury Compounds results in increased splicing of XBP1 mRNA]; Acetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [arsenic trioxide results in increased abundance of Reactive Oxygen Species]]; Acetylcysteine inhibits the reaction [XBP1 protein inhibits the reaction [Hydrogen Peroxide results in increased abundance of Reactive Oxygen Species]] | PMID:21138464 PMID:27511942 | XBP1 | multiple interactions | ISO | Xbp1 (Rattus norvegicus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [Arsenic Trioxide results in increased expression of XBP1 protein]; Acetylcysteine inhibits the reaction [Sodium Fluoride results in increased splicing of XBP1 mRNA] | PMID:21145380 PMID:30633982 | XBP1 | multiple interactions | ISO | Xbp1 (Mus musculus) | 6480464 | CTD | Acetylcysteine inhibits the reaction [chloroacetic acid results in increased expression of XBP1 protein alternative form]; Acetylcysteine inhibits the reaction [methylmercuric chloride results in increased expression of XBP1 protein alternative form]; Acetylcysteine inhibits the reaction [mono-(2-ethylhexyl)phthalate results in increased expression of XBP1 protein alternative form]; Acetylcysteine inhibits the reaction [sodium arsenite results in increased expression of XBP1 protein alternative form] | PMID:21911445 PMID:25451595 PMID:31330229 PMID:37692514 | | ||||||||||||||||||||||
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