GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | RELA | decreases expression | EXP | | 6480464 | CTD | Niclosamide results in decreased expression of RELA protein | PMID:27492973 | RELA | multiple interactions | EXP | | 6480464 | CTD | Imatinib Mesylate promotes the reaction [Niclosamide results in decreased expression of RELA protein]; Niclosamide inhibits the reaction [[Lapatinib results in decreased susceptibility to Lapatinib] which results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [TNF protein affects the localization of RELA protein]; Niclosamide inhibits the reaction [TNF protein results in increased activity of RELA protein]; Niclosamide inhibits the reaction [WNT3A protein affects the localization of RELA protein]; Niclosamide promotes the reaction [Imatinib Mesylate results in decreased expression of RELA protein]; Niclosamide results in decreased phosphorylation of and affects the localization of RELA protein | PMID:20215516 PMID:26116531 PMID:26643609 PMID:27492973 | RELA | multiple interactions | ISO | Rela (Mus musculus) | 6480464 | CTD | Niclosamide affects the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of RELA protein]; Niclosamide inhibits the reaction [[Adenosine Triphosphate co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of and results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [[CSF1 protein co-treated with TNFSF11 protein] results in increased phosphorylation of RELA protein]; Niclosamide inhibits the reaction [Doxorubicin results in increased expression of RELA protein modified form] | PMID:28318631 PMID:28824321 PMID:33524445 | RELA | multiple interactions | ISO | Rela (Rattus norvegicus) | 6480464 | CTD | Niclosamide inhibits the reaction [TGFB1 protein results in increased expression of RELA protein modified form] | PMID:28318631 | | ||||||||||||||||||||||
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