GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | RELA | affects localization | ISO | Rela (Rattus norvegicus) | 6480464 | CTD | Methotrexate affects the localization of RELA protein | PMID:33720507 | RELA | increases expression | ISO | Rela (Rattus norvegicus) | 6480464 | CTD | Methotrexate results in increased expression of RELA mRNA; Methotrexate results in increased expression of RELA protein | PMID:18535404 PMID:29935243 PMID:31362085 PMID:34737150 PMID:37341015 | RELA | multiple interactions | ISO | Rela (Rattus norvegicus) | 6480464 | CTD | 2,2-bis(4-glycidyloxyphenyl)propane inhibits the reaction [mangiferin inhibits the reaction [Methotrexate results in increased expression of and results in increased phosphorylation of RELA protein]]; Buspirone inhibits the reaction [Methotrexate results in increased expression of RELA mRNA]; Liraglutide inhibits the reaction [Methotrexate results in increased expression of RELA protein]; mangiferin inhibits the reaction [Methotrexate results in increased expression of and results in increased phosphorylation of RELA protein]; Methotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of and results in increased phosphorylation of RELA protein]; Methotrexate inhibits the reaction [Freund's Adjuvant results in increased expression of RELA mRNA]; Methotrexate inhibits the reaction [Freund's Adjuvant results in increased phosphorylation of RELA protein]; Methotrexate results in increased expression of and affects the localization of RELA protein; Perindopril inhibits the reaction [Methotrexate results in increased expression of RELA protein]; pimagedine inhibits the reaction [Methotrexate results in increased expression of and affects the localization of RELA protein]; vanillin inhibits the reaction [Methotrexate results in increased expression of RELA protein] | PMID:27613480 PMID:29216766 PMID:29935243 PMID:31362085 PMID:34737150 PMID:36249937 PMID:37341015 | | ||||||||||||||||||||||
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