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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:3305
Term: Calcimycin
Definition: An aminobenzoic acid that has formula C29H37N3O6.
Chemical ID: MESH:D000001
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAincreases response to substanceEXP 6480464CTDRELA gene mutant form results in increased susceptibility to CalcimycinPMID:11360202
RELAmultiple interactionsEXP 6480464CTD[Calcimycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of RELA protein; [Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein; [Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of RELA protein; chrysin inhibits the reaction [[Calcimycin co-treated with Tetradecanoylphorbol Acetate] affects the localization of RELA protein]; fisetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein]; galangin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of RELA protein]; myricetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein]; Plant Extracts inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of RELA protein]; Quercetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of and results in increased activity of RELA protein]; Quercetin inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of RELA protein]; RELA protein inhibits the reaction [Calcimycin results in increased expression of DDIT3 mRNA]; resveratrol inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with Calcimycin] affects the localization of RELA protein]PMID:11360202 PMID:17588137 PMID:18958421 PMID:19416633 PMID:19665545 PMID:21515303 PMID:22322153 PMID:23535185
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