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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:2781
Term: apocynin
Definition: An aromatic ketone that is 1-phenylethanone substituted by a hydroxy group at position 4 and a methoxy group at position 3.
Chemical ID: MESH:C056165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAmultiple interactionsEXP 6480464CTDacetovanillone inhibits the reaction [IL1B promotes the reaction [EP300 protein binds to RELA protein]]; acetovanillone inhibits the reaction [IL1B protein results in increased expression of RELA protein modified form]PMID:19281832 PMID:27393034
RELAmultiple interactionsISORela (Mus musculus)6480464CTDacetovanillone inhibits the reaction [[Maneb co-treated with Paraquat] results in increased phosphorylation of RELA protein]; acetovanillone inhibits the reaction [Cocaine results in increased phosphorylation of and results in increased activity of RELA protein]; acetovanillone inhibits the reaction [DMD gene mutant form results in increased expression of RELA protein modified form]; acetovanillone inhibits the reaction [TNF protein results in increased phosphorylation of RELA protein]PMID:19608869 PMID:20354174 PMID:26930420 PMID:28202386
RELAmultiple interactionsISORela (Rattus norvegicus)6480464CTDacetovanillone inhibits the reaction [RELA protein binds to MMP9 promoter]; acetovanillone inhibits the reaction [TNF protein affects the localization of RELA protein]PMID:23774252
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