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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1352761
Species: Homo sapiens
RGD Object: Gene
Symbol: RELA
Name: RELA proto-oncogene, NF-kB subunit
Acc ID: CHEBI:15600
Term: (+)-catechin
Definition: The (+)-enantiomer of catechin and a polyphenolic antioxidant plant metabolite.
Chemical ID: MESH:D002392
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
RELAdecreases expressionEXP 6480464CTDCatechin results in decreased expression of RELA mRNA; Catechin results in decreased expression of RELA proteinPMID:23706674
RELAmultiple interactionsEXP 6480464CTD[epigallocatechin gallate co-treated with gallocatechol co-treated with epicatechin gallate co-treated with Catechin analog] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RELA protein]; Catechin analog inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of RELA protein]; Catechin inhibits the reaction [Glucose affects the localization of RELA protein]PMID:19557821 PMID:26187476
RELAmultiple interactionsISORela (Mus musculus)6480464CTDCatechin inhibits the reaction [tert-Butylhydroperoxide affects the localization of RELA protein]; Catechin results in decreased expression of and results in decreased phosphorylation of RELA proteinPMID:15879681 PMID:34581093
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